What to Expect During Your First PRP Injection for Pain Relief

November 19, 2025

Platelet-rich plasma (PRP) therapy has emerged as a promising, minimally invasive option for those seeking relief from chronic pain conditions like plantar fasciitis, joint pain, and tendon injuries. If you’re considering PRP injections at Chronic Care of Richmond, you probably have questions about what the process involves, how to prepare, and what your recovery might look like. Here’s a comprehensive guide to help you confidently approach your first PRP treatment.



Understanding PRP: Harnessing Your Body’s Healing Power


PRP therapy utilizes a concentrated dose of your own platelets—tiny cell fragments in your blood that are rich in growth factors. When injected into an area of pain or injury, these platelets can help stimulate tissue repair and reduce inflammation. This innovative approach is gaining traction for conditions like plantar fasciitis, where traditional methods may not always provide lasting relief. PRP has demonstrated a significant ability to promote healing and improve pain outcomes in patients with chronic musculoskeletal conditions.


Preparing for Your PRP Injection: What to Do Before Your Appointment


Preparation for a PRP injection is straightforward but important for ensuring the best possible results. In the days leading up to your appointment, your provider at Chronic Care of Richmond may advise you to:


  • Hydrate well to ensure an easy blood draw, as your blood is the source of the platelets used in the procedure.
  • Avoid anti-inflammatory medications such as ibuprofen or aspirin for a certain period, since these can interfere with the platelets’ healing abilities.
  • Eat a healthy meal on the day of your procedure and wear comfortable clothing that allows easy access to the injection area.


Communication is key—let your provider know about any medications you’re taking or health conditions you have. This helps tailor the process to your specific needs. For more details on how to prepare, you can visit our PRP Therapy page.


The PRP Injection Experience: Step-by-Step


When you arrive for your PRP injection, you’ll be greeted by our caring team and guided through each step of the process:


  1. Blood Draw: A small sample of your blood is collected, usually from your arm, using a standard needle. This is generally quick and causes minimal discomfort.
  2. Centrifugation: The blood sample is placed in a centrifuge, a device that spins rapidly to separate the platelets from other blood components. This process typically takes about 10 to 15 minutes.
  3. Preparation of PRP: The concentrated platelet-rich plasma is drawn into a syringe, ready for injection.
  4. Targeted Injection: Using ultrasound guidance for precision, your provider injects the PRP directly into the affected area. For conditions like plantar fasciitis, this means targeting the inflamed tissue to promote healing at the source.


Most patients describe the injection as a brief, tolerable pinch. The procedure is usually completed in less than an hour, allowing you to return home the same day.


Aftercare: Supporting Your Recovery


Proper aftercare is crucial to optimize the benefits of PRP therapy. Immediately following your injection, you may notice mild swelling, soreness, or bruising at the site—these are normal signs that your body is responding to the treatment. Applying a cold pack and keeping the area elevated can help minimize discomfort.


Your provider will offer personalized guidance, but general recommendations include:


  • Resting the treated area for a few days and avoiding strenuous activities.
  • Refraining from taking anti-inflammatory medications for a week or more post-injection, as these can counteract the platelet activity.
  • Gradually reintroducing physical activity as directed, often paired with physical therapy for optimal results.


If you have questions or concerns during your recovery, our team at Chronic Care of Richmond is always available to support you.


Recovery Timeline: What Most Patients Experience


The healing process with PRP is gradual, as the therapy encourages your body to regenerate tissue over time. Here’s what you can generally expect:


  • First few days: Mild discomfort or swelling, which typically resolves quickly.
  • 1-2 weeks post-injection: Early signs of improvement may appear, though some conditions require more time.
  • 4-6 weeks: Noticeable pain relief and improved function are common, especially as damaged tissues continue to heal.
  • Three months and beyond: Maximum benefits are often seen as the body completes its natural repair process. In some cases, a series of injections may be recommended for best results.


It’s important to remember that individual responses to PRP therapy can vary based on the severity of the condition and personal health factors. Your provider will monitor your progress and adjust your treatment plan as needed.


Why Choose PRP at Chronic Care of Richmond?


At Chronic Care of Richmond, we are dedicated to providing evidence-based, patient-centered care for those seeking alternatives to surgery and long-term medication use. Our team has extensive experience in regenerative therapies, ensuring your PRP procedure is safe, comfortable, and tailored to your unique needs.


Empowering You on Your Pain Relief Journey


Deciding to pursue PRP therapy is a positive step toward managing pain and reclaiming your quality of life. By understanding what to expect during your first PRP injection, you can approach your appointment at Chronic Care of Richmond with confidence and peace of mind.


If you're ready to take the next step or have questions about PRP for pain relief, our team is here to help guide you through every stage of the process. Discover how PRP therapy could make a difference for you by requesting a consultation today.

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